Biologists investigating basic problems feel fulfilled when their investigations lead to practical application. On August 3, 1492, Christopher Columbus left the port of Palos for the Canary Islands, to begin, on September 6, the crossing of the ocean sea. When leaving La Gomera. Wounds produced by burns. This line of work led to the creation of a Treatment diseases cultures new method for the growth of human epidermal cells in culture and, In 1979, To its use to regenerate epidermis in third degree burns. Over time, The application of these crops became widespread in the treatment of other diseases. Although it may seem unlikely that the study of a mouse tumor led to the treatment of burns in man, the two issues are related, Although the link is not obvious.
The biological activity of the vascular endothelium
Ore than 20 years have passed since Lord Howard Florey prophetically proposed that “Vascular endothelial cells are more than a layer of nucleated cellophane.” Since then, The multiple functions of the vascular endothelium, The layer of cells that line the vessels, Have been clearly defined with regard to capillary transport, Regulation of plasma lipids, Baskets business email list Hemostasis, Control of vascular tone, Modulation of function. platelet, Development and remodeling of blood vessels. The endothelium performs these functions through the synthesis and secretion of substances endowed with biological activity; Including interleukin-1, Endothelial cell growth factor, Platelet-derived growth factor, Factors, Prostacyclin, RELATED CONTENT The endothelium, A key organ We can affirm that the vascular endothelium meets all the necessary requirements to be considered a true internal secretion cell.
Cell cycle control
Which releases extracellular messengers with mainly paracrine (that is, Communication between cells) and (that is, Communication within the cell) functions. cell). But, in addition, The vascular endothelium possesses the enzymatic machinery necessary to metabolize other vasoactive substances: angiotensin, , Norepinephrine and serotonin. In this article we will review different aspects of two of the main substances produced by the vascular endothelium; We refer to. Both are powerful vasodilators and platelet aggregation inhibitors; Its description has Sale Lead led to the rethinking and redefinition of many important aspects of vascular physiology and pathophysiology. My PhD student James were investigating mouse , Tumors that have stem cells capable of producing somatic cells of multiple types. After successive experiments, We achieved the conditions that allowed the proliferation of colonies of an unusual cell type. Examined, A broad category that includes cells of the epidermis, The outermost layer of the skin.
